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Cardiology
arrhythmias
asystole
A 62-year-old woman presents to her primary care provider reporting persistent daytime lethargy, difficulty concentrating, and new-onset nocturnal palpitations described as "skipped beats" and occasional forceful pounding in her chest. Her husband reports loud snoring and several observed episodes of breathing cessation during sleep, often followed by gasps. She has also noticed a general decline in her energy levels and has gained weight over the past year. Her medical history includes well-controlled hypertension for which she takes lisinopril. She denies chest pain, dyspnea, or syncope. On physical examination, her blood pressure is 148/86 mm Hg, pulse is 72/min, and oxygen saturation is 96% on room air. Her body mass index (BMI) is 34 kg/m2, and her neck circumference is 42 cm. A 24-hour ambulatory ECG monitoring reveals frequent nocturnal premature ventricular contractions, several episodes of bradycardia with heart rates dropping to 35 beats/min, a 6-second sinus pause, and a paroxysm of atrial fibrillation with a rapid ventricular response (135 beats/min) occurring in the early morning hours. Based on these findings, which of the following is the most appropriate diagnostic evaluation and initial management strategy for this patient?
| Lab Parameter | Value | Reference Range |
|---|---|---|
| Hemoglobin | 165 g/L | 120-150 g/L |
| TSH | 2.1 mIU/L | 0.4-4.0 mIU/L |
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