_id

683a1656c782e11e38d1b36a

id

10517

title

International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Assessment

full_title

International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Assessment

short_title

IOTA Simple Rules Risk Assessment

med_description

Predicts risk of malignancy in adnexal masses using ultrasound features.

short_description

Ovarian cancer risk.

slug

international-ovarian-tumor-analysis-iota-simple-rules-risk-assessment

description

The International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Score predicts risk of malignancy in adnexal masses using ultrasound features.

keywords

International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Assessment, IOTA, IOTA Simple Rules Risk Assessment, simple rules, simple rules risk score, simple rules risk assessment, ovarian tumor risk, ovarian cancer risk, adnexal masses malignancy

complaint

[ "Abdominal Pain", "Back Pain", "Bleeding", "Constipation", "Fatigue", "Polyuria", "Swelling", "Weight Loss/Gain" ]

formula

The model coefficients to calculate the risk of malignancy in adnexal masses are as follows: Risk of malignancy, % = [ex/(1 + ex)]*100, where x = Σ(β*variable)

evidence

measurements

[]

information

refrences

{ "Clinical Practice Guidelines": [], "Manufacturer Website": [], "Original/Primary Reference": [ { "href": "https://pubmed.ncbi.nlm.nih.gov/26800772/", "text": "Timmerman D, Van Calster B, Testa A, et al. Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group. Am J Obstet Gynecol. 2016;214(4):424-437." } ], "Other References": [ { "href": "https://pubmed.ncbi.nlm.nih.gov/18504770/", "text": "Timmerman D, Testa AC, Bourne T, et al. Simple ultrasound-based rules for the diagnosis of ovarian cancer. Ultrasound Obstet Gynecol. 2008;31(6):681-690." }, { "href": "https://pubmed.ncbi.nlm.nih.gov/29709594/", "text": "Nohuz E, De Simone L, Chêne G. Reliability of IOTA score and ADNEX model in the screening of ovarian malignancy in postmenopausal women. J Gynecol Obstet Hum Reprod. 2019;48(2):103-107." }, { "href": "https://pubmed.ncbi.nlm.nih.gov/24920435/", "text": "Nunes N, Ambler G, Foo X, Naftalin J, Widschwendter M, Jurkovic D. Use of IOTA simple rules for diagnosis of ovarian cancer: meta-analysis. Ultrasound Obstet Gynecol. 2014;44(5):503-514." }, { "href": "https://pubmed.ncbi.nlm.nih.gov/34533862/", "text": "Hiett AK, Sonek JD, Guy M, Reid TJ. Performance of IOTA Simple Rules, Simple Rules risk assessment, ADNEX model and O-RADS in differentiating between benign and malignant adnexal lesions in North American women. Ultrasound Obstet Gynecol. 2022;59(5):668-676." } ], "Outcomes": [], "Validation": [ { "href": "https://pubmed.ncbi.nlm.nih.gov/26800772/", "text": "Timmerman D, Van Calster B, Testa A, et al. Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group. Am J Obstet Gynecol. 2016;214(4):424-437." } ], "Validations": [] }

pearls

• The use of this score requires that the user understand ultrasound terminology and findings. 
• For additional definitions of the imaging features described in this score, see the IOTA group report here.

usecase

• In patients who are undergoing adnexal surgery. 
• Not for use in patients who are being treated with observation or other conservative measures. 

reasons

The original Simple Rules study provided a list of 5 benign characteristics and 5 malignant characteristics. An ultrasound report was classified as malignant or benign if findings met all 5 characteristics in one of the groups. Ultrasound reports which showed a mix of these characteristics were classified as “indeterminate” which limited the score’s clinical use. Study authors created a logistic regression model in 2016 and added another input; the location where the ultrasound imaging was performed. This enhanced model with risk calculation is what MDCalc has chosen to include.

next_advice

next_actions

next_management

• M features are more closely associated with malignancy while B features are more associated with a benign tumor. 
• The presence of M features increases the risk of a tumor being malignant while the presence of B features will decrease the risk. 
• Use as part of presurgical counseling and planning with your patient. Remember to only use this score in patients who are undergoing surgery.

diseases

[ "Cancer", "Ovarian Cancer" ]

input_schema

[ { "conditionality": null, "default": null, "label_en": "<p>B1 (unilocular cyst)</p>", "mdcalc_info_concept": null, "name": "b1", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": -3.41 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>B2 (solid components present, but &lt;7 mm)</p>", "mdcalc_info_concept": null, "name": "b2", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": -2.25 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>B3 (acoustic shadows)</p>", "mdcalc_info_concept": null, "name": "b3", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": -1.66 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>B4 (smooth multilocular tumor with largest diameter &lt;100 mm)</p>", "mdcalc_info_concept": null, "name": "b4", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": -2.75 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>B5 (no blood flow; color score 1)</p>", "mdcalc_info_concept": null, "name": "b5", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": -1.86 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>M1 (irregular solid tumor)</p>", "mdcalc_info_concept": null, "name": "m1", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 2.19 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>M2 (ascites)</p>", "mdcalc_info_concept": null, "name": "m2", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 2.65 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>M3 (at least 4 papillary structures)</p>", "mdcalc_info_concept": null, "name": "m3", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 1.53 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>M4 (irregular multilocular solid tumor with largest diameter &ge;100 mm)</p>", "mdcalc_info_concept": null, "name": "m4", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 0.98 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>M5 (very strong flow; color score 4)</p>", "mdcalc_info_concept": null, "name": "m5", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 1.55 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": null, "default": null, "label_en": "<p>Ultrasound examination at oncology center</p>", "mdcalc_info_concept": null, "name": "location", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 0.92 } ], "show_points": false, "tips_en": "", "type": "radio" } ]

instructions

This tool provides an estimated risk of malignancy in patients who are undergoing adnexal surgery.

published

2024-04-12T19:40:35.604Z

purpose

[ "Prognosis" ]

search_terms

[ "International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Assessment", "IOTA", "IOTA Simple Rules Risk Assessment", "simple rules", "simple rules risk score", "simple rules risk assessment", "ovarian tumor risk", "ovarian cancer risk", "adnexal masses malignancy" ]

seo

{ "keywords_en": "International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Assessment, IOTA, IOTA Simple Rules Risk Assessment, simple rules, simple rules risk score, simple rules risk assessment, ovarian tumor risk, ovarian cancer risk, adnexal masses malignancy", "meta_description_en": "The International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Score predicts risk of malignancy in adnexal masses using ultrasound features." }

specialty

[ "Family Practice", "Hematology and Oncology", "Hospitalist Medicine", "Internal Medicine", "OB-Gyn", "Primary Care", "Surgery (General)" ]

departments

[ "Oncologic", "Reproductive" ]

tags

[]

version_number

1

versions

[]

related

[ { "calcId": 10553, "short_title_en": "DELTA-P Score", "slug": "dutch-english-lems-tumor-association-prediction-delta-p-score" }, { "calcId": 10425, "short_title_en": "CRASH", "slug": "chemotherapy-risk-assessment-scale-high-age-patients-crash-score" }, { "calcId": 10541, "short_title_en": "ORAI", "slug": "osteoporosis-risk-assessment-instrument-orai" } ]

ismed

false

section

[ "whenToUseViewed", "pearlsPitfallsViewed", "whyUseViewed", "nextStepsViewed", "evidenceViewed" ]

cleaned_departments

[ "oncology", "gynecology" ]

cleaned_use

[ "In patients who are undergoing adnexal surgery.", "Not for use in patients who are being treated with observation or other conservative measures." ]

pub

false