_id

683a1624c782e11e38d1b20f

id

4065

title

Blood Volume Calculation

full_title

Blood Volume Calculation

short_title

Blood Volume Calculation

med_description

Calculates total blood volume, red blood cell volume, and plasma volume.

short_description

Blood and blood components volumes.

slug

blood-volume-calculation

description

The Blood Volume Calculation Calculates total blood volume, red blood cell volume, and plasma volume.

keywords

blood, volume, blood volume, red blood cell, blood cell, plasma, plasma volume

complaint

[ "Bleeding" ]

formula

Total blood volume, L (adults and children ≥25 kg)

• Male = [ 0.3669 × (height, m)³ + 0.03219 × (weight, kg) + 0.6041 ] 
• Female = [ 0.3561 × (height, m)³ + 0.03308 × (weight, kg) + 0.1833 ]

Total blood volume, mL (neonates and children <25 kg) = weight, kg × Y, where Y is as follows:

• Preterm neonate: 100 mL/kg
• Term neonate: 85 mL/kg
• Infant aged 1-4 months: 75 mL/kg
• Child <25 kg: 70 mL/kg

RBC volume, mL = total blood volume, mL × hematocrit / 100

Plasma volume, mL = total blood volume, mL × ( 1 – hematocrit / 100 )

Example: adult male, height = 180 cm, weight = 70 kg, Hct = 25%

• Total blood volume, L
• = [ 0.3669 × (height, m)³ + 0.03219 × (weight, kg) + 0.6041 ]
• = [ 0.3669 × (180 / 100)³ + 0.03219 × (70) + 0.6041 ]
• = 2.1398 + 2.2533 + 0.6041
• = 5.0 L (4,997 mL)
• Red blood cell volume, mL
  • = (4,997 mL) × (25% / 100)
  • = 4,997 mL × 0.25
  • = 1,249 mL
• Plasma volume, mL
  • = 4,997 mL × [1 - (25% / 100)]
  • = 4,997 mL × 0.75
  • = 3,748 mL

evidence

measurements

[ { "name": "weight, peds", "unit": "wt_peds", "error_min": "0", "error_max": "55", "warn_min": "10", "warn_max": "55", "conversion": "0.453592", "normal_max_si": "25", "normal_max_us": "55", "normal_min_si": "4", "normal_min_us": "10", "units_si": "kg", "units_us": "lbs" }, { "name": "Fetal weight", "unit": "wt_fetus", "error_min": "0", "error_max": "320", "warn_min": "21", "warn_max": "320", "conversion": "28.3495", "normal_max_si": "4000", "normal_max_us": "160", "normal_min_si": "600", "normal_min_us": "21", "units_si": "g", "units_us": "oz" }, { "name": "Hematocrit", "unit": "hct", "error_min": "1", "error_max": "70", "warn_min": "20", "warn_max": "55", "conversion": "1", "normal_max_si": "51", "normal_max_us": "51", "normal_min_si": "36", "normal_min_us": "36", "units_si": "%", "units_us": "%" }, { "name": "Weight, infant 1-4 months", "unit": "wt_infant", "error_min": "0", "error_max": "100", "warn_min": "3", "warn_max": "50", "conversion": "0.453592", "normal_max_si": "8.5", "normal_max_us": "20", "normal_min_si": "3", "normal_min_us": "6", "units_si": "kg", "units_us": "lbs" }, { "name": "Height", "unit": "ht", "error_min": "0", "error_max": "90", "warn_min": "5", "warn_max": "80", "conversion": "2.54", "normal_max_si": "213", "normal_max_us": "84", "normal_min_si": "152", "normal_min_us": "60", "units_si": "cm", "units_us": "in" }, { "name": "Weight, adult", "unit": "wt_adult", "error_min": "55", "error_max": "620", "warn_min": "55", "warn_max": "300", "conversion": "0.453592", "normal_max_si": "113", "normal_max_us": "250", "normal_min_si": "45", "normal_min_us": "100", "units_si": "kg", "units_us": "lbs" } ]

information

refrences

{ "Clinical Practice Guidelines": [], "Manufacturer Website": [], "Original/Primary Reference": [ { "href": "https://www.ncbi.nlm.nih.gov/pubmed/21936146", "text": "Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51(2):224-32." } ], "Other References": [ { "href": "https://www.ncbi.nlm.nih.gov/nlmcatalog/101666102", "text": "Brecher ME, Shaz BH, Schwartz J. Look This Up, Too! A Quick Reference in Apheresis. 3rd Ed. AABB Press, Bethesda MD 2013." } ], "Outcomes": [], "Validation": [], "Validations": [] }

pearls

Total blood volume is calculated using Nadler’s equation.

usecase

Use when blood volumes are needed (e.g. RBC exchange, plasma exchange, coagulation factor drug dosing, RhIG dosing calculations).

reasons

next_advice

If dosing for RBC exchange, use in conjunction with Sickle Cell RBC Exchange Volume.

next_actions

next_management

diseases

[ "Anemia", "Hematologic Malignancy" ]

input_schema

[ { "conditionality": "", "default": null, "label_en": "Patient", "mdcalc_info_concept": null, "name": "patient", "option_fhir_rules": null, "optional": false, "options": [ { "label": "Preterm neonate", "value": 0 }, { "label": "Term neonate", "value": 1 }, { "label": "Infant aged 1-4 months", "value": 2 }, { "label": "Child <25 kg (55 lbs)", "value": 3 }, { "label": "Child ≥25 kg (55 lbs) or adult", "value": 4 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": "patient == 4", "default": null, "label_en": "Sex", "mdcalc_info_concept": null, "name": "sex", "option_fhir_rules": null, "optional": false, "options": [ { "label": "Male", "value": 0 }, { "label": "Female", "value": 1 } ], "show_points": false, "tips_en": "", "type": "radio" }, { "conditionality": "patient == 4", "default": null, "fhir_rules": null, "inct": null, "label_en": "Height", "name": "height", "optional": false, "tips_en": "", "type": "textbox", "unit": "ht" }, { "conditionality": "", "default": null, "fhir_rules": null, "inct": null, "label_en": "Hematocrit", "name": "hematocrit", "optional": true, "tips_en": "Optional, to calculate RBC and plasma volume", "type": "textbox", "unit": "hct" }, { "conditionality": "patient == 4", "default": null, "fhir_rules": null, "inct": null, "label_en": "Weight", "name": "weight", "optional": false, "tips_en": "", "type": "textbox", "unit": "wt_adult" }, { "conditionality": "patient <= 1", "default": null, "fhir_rules": null, "inct": null, "label_en": "Weight", "name": "weight_baby", "optional": false, "tips_en": "", "type": "textbox", "unit": "wt_fetus" }, { "conditionality": "patient == 2", "default": null, "fhir_rules": null, "inct": null, "label_en": "Weight", "name": "weight_infant", "optional": false, "tips_en": "", "type": "textbox", "unit": "wt_infant" }, { "conditionality": "patient == 3", "default": null, "fhir_rules": null, "inct": null, "label_en": "Weight", "name": "weight_peds", "optional": false, "tips_en": "", "type": "textbox", "unit": "wt_peds" } ]

instructions

published

2022-04-21T20:29:42.030Z

purpose

[ "Formula" ]

search_terms

[ "blood", "rbc", "plasma volume", "rbc volume", "red blood cell volume", "erythrocytes", "total blood volume", "tbv" ]

seo

{ "keywords_en": "blood, volume, blood volume, red blood cell, blood cell, plasma, plasma volume", "meta_description_en": "The Blood Volume Calculation Calculates total blood volume, red blood cell volume, and plasma volume." }

specialty

[ "Critical Care", "Hematology and Oncology", "Hospitalist Medicine", "Internal Medicine", "Pathology", "Surgery (Trauma)", "Transfusion Medicine" ]

departments

[ "Hematologic" ]

tags

[]

version_number

1

versions

[]

related

[ { "calcId": 4066, "short_title_en": "Sickle Cell RBC Exchange Volume", "slug": "sickle-cell-rbc-exchange-volume" }, { "calcId": 10534, "short_title_en": "Mentzer Index", "slug": "mentzer-index" }, { "calcId": 10012, "short_title_en": "DLI Volume", "slug": "donor-lymphocyte-infusion-dli-volume" } ]

ismed

true

section

[ "whenToUseViewed", "pearlsPitfallsViewed", "nextStepsViewed", "evidenceViewed" ]

cleaned_departments

[ "hematology" ]

cleaned_use

[ "Use when blood volumes are needed (e.g. RBC exchange, plasma exchange, coagulation factor drug dosing, RhIG dosing calculations)." ]

pub

false