_id

683a162cc782e11e38d1b242

id

10053

title

Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

full_title

Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

short_title

Binet Staging for CLL

med_description

Stages chronic lymphocytic leukemia, similar toRai Staging System.

short_description

CLL stage classification.

slug

binet-staging-system-chronic-lymphocytic-leukemia-cll

description

The Binet Staging System for Chronic Lymphocytic Leukemia (CLL) stages chronic lymphocytic leukemia, similar to Rai classification.

keywords

Binet staging system, Rai staging system, CLL, chronic lymphocytic leukemia

complaint

[ "Abdominal Pain", "Fatigue", "Fever", "Weight Loss/Gain" ]

formula

Selection of the appropriate features: *Nodal areas: cervical, axillary, inguinal (one side or both), spleen, and liver.

evidence

measurements

[]

information

Interpretation:

From Nabhan 2014.

refrences

{ "Clinical Practice Guidelines": [ { "href": "", "text": "" } ], "Manufacturer Website": [ { "href": "", "text": "" } ], "Original/Primary Reference": [ { "href": "https://www.ncbi.nlm.nih.gov/pubmed/890666", "text": "Binet JL, Leporrier M, Dighiero G, et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer. 1977;40(2):855-64." } ], "Other References": [ { "href": "https://www.ncbi.nlm.nih.gov/pubmed/25461996", "text": "Nabhan C, Rosen ST. Chronic lymphocytic leukemia: a clinical review. JAMA. 2014;312(21):2265-76." } ], "Outcomes": [ { "href": "", "text": "" } ], "Validation": [ { "href": "", "text": "" } ], "Validations": [] }

pearls

• Does not include molecular or genetic risk factors, which are critical in influencing prognosis and predicting treatment response.

• Keep in mind that as treatments have evolved, median overall survival estimates have improved. Survival estimates from the original publication are significantly shorter than those currently expected. The survival data referenced in this tool are based on those documented in Nabhan et al., 2014.

usecase

Use when evaluating a patient newly diagnosed with CLL.

reasons

Similar to theRai Staging System, this is a standardized method widely applied in both clinical practice and research settings. Based on straightforward physical examination findings and routine laboratory data. Helps classify CLL into risk categories, providing an estimate of prognosis which can inform treatment decisions.

next_advice

Stage alone should not dictate treatment; consider symptoms and patient comorbidities. Use clinical judgment and specialist recommendations to guide management decisions.

next_actions

next_management

• Low risk (stage A):
  • Monitor with a "watch and wait" approach unless symptoms or disease progression occurs.
  • Focus on regular follow-ups and patient education.
• Intermediate risk (stage B):
  • A “watch and wait” approach may be appropriate for asymptomatic individuals.
  • Assess for additional prognostic factors and signs of disease progression.
  • Consider initiating treatment if symptomatic or if there is rapid progression.
• High risk (stage C):
  • Initiate appropriate therapy based on patient and tumor characteristics, as well as goals of care.
  • Evaluate for clinical trials, especially in cases of high-risk genetic mutations.
• For early-stage, asymptomatic CLL (stages A and B), consider the IPS-E to predict the time to first treatment, helping to reaffirm treatment decisions and guide monitoring frequency.

diseases

[ "Cancer", "Hematologic Malignancy" ]

input_schema

[ { "conditionality": "", "default": 0, "label_en": "Areas of lymphadenopathy", "mdcalc_info_concept": null, "name": "areas", "option_fhir_rules": null, "optional": false, "options": [ { "label": "<3", "value": 0 }, { "label": "≥3", "value": 1 } ], "show_points": false, "tips_en": "Cervical, axillary, inguinal, spleen, and liver", "type": "radio" }, { "conditionality": "", "default": 0, "label_en": "Anemia", "md_calc_info_concept": null, "name": "anemia", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 1 } ], "show_points": false, "tips_en": "Hgb <10 g/dL", "type": "toggle" }, { "conditionality": "", "default": 0, "label_en": "Thrombocytopenia", "md_calc_info_concept": null, "name": "thrombocytopenia", "option_fhir_rules": null, "optional": false, "options": [ { "label": "No", "value": 0 }, { "label": "Yes", "value": 1 } ], "show_points": false, "tips_en": "Platelets <100,000/mm³", "type": "toggle" } ]

instructions

published

2022-04-21T20:28:11.585Z

purpose

[ "Diagnosis" ]

search_terms

[ "Binet staging system", "chronic lymphocytic leukemia ", "CLL" ]

seo

{ "keywords_en": "Binet staging system, Rai staging system, CLL, chronic lymphocytic leukemia", "meta_description_en": "The Binet Staging System for Chronic Lymphocytic Leukemia (CLL) stages chronic lymphocytic leukemia, similar to Rai classification." }

specialty

[ "Hematology and Oncology" ]

departments

[ "Hematologic", "Oncologic" ]

tags

[]

version_number

1

versions

[]

related

[ { "calcId": 10054, "short_title_en": "Rai Staging for CLL", "slug": "rai-staging-system-chronic-lymphocytic-leukemia-cll" }, { "calcId": 10565, "short_title_en": "IPS-E", "slug": "international-prognostic-score-asymptomatic-early-stage-cll-ips-e" }, { "calcId": 10562, "short_title_en": "BALL Score", "slug": "ball-score-relapsed-refractory-cll" } ]

ismed

false

section

[ "whenToUseViewed", "pearlsPitfallsViewed", "whyUseViewed", "nextStepsViewed", "evidenceViewed" ]

cleaned_departments

[ "hematology", "oncology" ]

cleaned_use

[ "Use when evaluating a patient newly diagnosed with CLL." ]

pub

false