_id

683a162bc782e11e38d1b23e

id

10049

title

Age-Adjusted ESR/CRP for Rheumatoid Arthritis

full_title

Age-Adjusted ESR/CRP for Rheumatoid Arthritis

short_title

Age-Adjusted ESR/CRP for RA

med_description

Calculates age-adjusted ESR and CRP in adult patients with rheumatoid arthritis.

short_description

Adjusted ESR/CRP calculation.

slug

age-adjusted-esr-crp-rheumatoid-arthritis

description

The Age-Adjustment Calculator for ESR and CRP calculates age-adjusted ESR and CRP in patients with late-onset and younger-onset rheumatoid arthritis.

keywords

Erythrocyte sedimentation rate, c-reactive protein values, ESR, CRP, age adjustment, age-adjustment, rheumatoid arthritis

complaint

[ "Joint Pain", "Pain" ]

formula

Male: ESR upper limit of normal, mm/hr = age / 2 CRP upper limit of normal, mg/dL = age / 50 Female: ESR upper limit of normal, mm/hr = (age + 10) / 2 CRP upper limit of normal, mg/dL = (age / 50) + 0.6

evidence

measurements

[ { "name": "Age", "unit": "age_adult", "error_min": "18", "error_max": "110", "warn_min": "18", "warn_max": "110", "conversion": "1", "normal_max_si": "0", "normal_max_us": "0", "normal_min_si": "0", "normal_min_us": "0", "units_si": "years", "units_us": "years" } ]

information

refrences

{ "Clinical Practice Guidelines": [ { "href": "", "text": "" } ], "Manufacturer Website": [ { "href": "", "text": "" } ], "Original/Primary Reference": [ { "href": "https://pubmed.ncbi.nlm.nih.gov/11036829/", "text": "Wener MH, Daum PR, McQuillan GM. The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration. J Rheumatol. 2000;27(10):2351-2359." }, { "href": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1546487/", "text": "Miller A, Green M, Robinson D. Simple rule for calculating normal erythrocyte sedimentation rate. Br Med J (Clin Res Ed). 1983;286(6361):266." } ], "Other References": [ { "href": "https://www.jrheum.org/content/32/6/1040.tab-article-info", "text": "Ranganath VK, Elashoff DA, Khanna D, et al. Age adjustment corrects for apparent differences in erythrocyte sedimentation rate and C-reactive protein values at the onset of seropositive rheumatoid arthritis in younger and older patients. J Rheumatol. 2005;32(6):1040-2." } ], "Outcomes": [ { "href": "", "text": "" } ], "Validation": [ { "href": "", "text": "" } ], "Validations": [] }

pearls

Besides age and sex, acute phase reactants can be influenced by various other factors, including anemia, pregnancy, kidney disease, and certain medications. These factors should be taken into account when interpreting results.

usecase

• Use when measuring erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels in the clinical setting, particularly to assess disease activity in rheumatoid arthritis (RA).
• May be utilized in the diagnostic evaluation and monitoring of other inflammatory conditions.

reasons

Age-adjusted values account for physiological increases in acute phase reactants with age, reducing false positives and unnecessary diagnostics and treatments in older patients.

next_advice

• Always consider the clinical presentation and other diagnostic findings alongside ESR and CRP levels.
• Use in conjunction with other tests to differentiate between types of inflammatory and non-inflammatory conditions.
• Elevated ESR and CRP are not diagnostic on their own and can be elevated in a variety of conditions, including infections, malignancies, and autoimmune diseases.
• If elevated, initiate or escalate investigations to identify the underlying cause, such as imaging studies or specific autoimmune panels.
• In chronic inflammatory conditions, results may be used to monitor disease activity and guide management, which can include modifying or initiating anti-inflammatory or immunosuppressive therapies.
• Schedule regular follow-ups to monitor ESR and CRP trends, adjusting treatment plans as necessary.

next_actions

next_management

diseases

[ "Rheumatoid Arthritis" ]

input_schema

[ { "conditionality": "", "default": 0, "label_en": "<p>Sex</p>", "md_calc_info_concept": null, "name": "sex", "option_fhir_rules": null, "optional": false, "options": [ { "label": "Male", "value": 0 }, { "label": "Female", "value": 1 } ], "show_points": false, "tips_en": "", "type": "toggle" }, { "conditionality": "", "default": null, "fhir_rules": null, "inct": null, "label_en": "<p>Age</p>", "name": "age", "optional": false, "tips_en": "", "type": "textbox", "unit": "age_adult" } ]

instructions

published

2022-04-21T20:28:11.013Z

purpose

[ "Formula" ]

search_terms

[ "Erythrocyte sedimentation rate", "c-reactive protein values", "ESR", "CRP", "age adjustment", "age-adjustment", "rheumatoid arthritis" ]

seo

{ "keywords_en": "Erythrocyte sedimentation rate, c-reactive protein values, ESR, CRP, age adjustment, age-adjustment, rheumatoid arthritis", "meta_description_en": "The Age-Adjustment Calculator for ESR and CRP calculates age-adjusted ESR and CRP in patients with late-onset and younger-onset rheumatoid arthritis." }

specialty

[ "Family Practice", "Internal Medicine", "Orthopedics", "Primary Care", "Rheumatology" ]

departments

[ "Musculoskeletal", "Rheumatologic" ]

tags

[]

version_number

1

versions

[]

related

[ { "calcId": 2193, "short_title_en": "DAS28-CRP for Rheumatoid Arthritis", "slug": "disease-activity-score-28-rheumatoid-arthritis-crp-das28-crp" }, { "calcId": 2176, "short_title_en": "DAS28-ESR for Rheumatoid Arthritis", "slug": "disease-activity-score-28-rheumatoid-arthritis-esr-das28-esr" }, { "calcId": 2194, "short_title_en": "SDAI for Rheumatoid Arthritis", "slug": "simple-disease-activity-index-sdai-rheumatoid-arthritis" } ]

ismed

false

section

[ "whenToUseViewed", "pearlsPitfallsViewed", "whyUseViewed", "nextStepsViewed", "evidenceViewed" ]

cleaned_departments

[ "orthopedics", "rheumatology" ]

cleaned_use

[ "Use when measuring erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels in the clinical setting, particularly to assess disease activity in rheumatoid arthritis (RA).", "May be utilized in the diagnostic evaluation and monitoring of other inflammatory conditions." ]

pub

false